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| 发布时间：2019-05-20 访问次数:683 作者: |
contact information office:room 719, researching building 18 email:  office phone: 86 21 6425 0823 office fax: 86 21 6425 0823
education 1999.07 ph.d. physiology, beijing university of chinese medicine beijing, p. r. china 1990.07 m.sc. pathophysiology, shanxi medical university, taiyuan, p. r. china 1985.07 bm. medicine, shanxi medical university, taiyuan, p. r. china
professional experience positions: 2009-now: professor, east china university of science & technology, shanghai, china. 2005-2007: professor, shanghai institute of materia medica, chinese academy of sciences, china. 2001-2005: associate professor, dept. of neuropharmacology, shanghai institute of materia medica, chinese academy of sciences, china 1993-1996: lecturer and research fellow, dept. of pathophysiology and institute of hepatic disease, shanxi medical university. taiyuan, china. 1985-1987: research assistant, dept. of pathophysiology and institute of hepatic disease, shanxi medical university. taiyuan, china.
research fellowships: 2007–2009 visiting scientist, university of wisconsin-madison, usa. 2002–2003 research follow, mayo clinic. usa. 2001 research associate fellow, hong kong university of science & technology. hong kong. 1999–2001 postdoctoral research fellow, shanghai institute of materia medica, chinese academy of sciences, shanghai, china.
editorial board international journal of clinical and experimental medicine international journal of physiology, pathophysiology and pharmacology
honors: 2005 debio-ccrf china prize encouraging prize. 2000 distinguished young scientist, shanghai institute of materia medica 1994 distinguished teacher, shanxi medical university 1991 member of chinese association of pathophysiology society
research interests mechanism studies on alzheimer’s disease, biological significance of oxidized -amyloid peptides degradation enzymes on -amyloid protein deposition. r&d of the drugs of anti-dementia, anti-depression and anti-schizophrenia. screening of novel anti-inflammatory drugs, focusing on pharmacodynamics and pathogenesis of autoimmune diseases including rheumatoid arthritis, ulcerative colitis, multiple sclerosis and myasthenia gravis.
publication z. su, y. shi, z. lu, r. l, x. wang, b. ning, j. duan, y. zhu, y. li, j. duan, c. hao, r. wang. comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with srt1720 for the protection of h2o2-induced senescent endothelium. g. yang, s. ge y. wu, j. huang, s. li*, r. wang*, l. ma*. design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-alzheimer agents. eur. j. med. chem, (2018) 156, 206-215. y. ti, l. yu, y. tang, t. jin, m yang, r. wang,∗,y. xu, w. zhu,∗ a hypoxia-activated near infrared fluorescent probe forcyclooxygenase-2 and in vivo imaging for tumor and inflammation. sensors and actuators b 265 (2018) 582–590. c. huang, d. dong, q. jiao, h. pan, l. ma, r. wang*. sarsasapogenin-aa13 ameliorates aβ- induced cognitive deficits via improving neuroglial capacity on aβ clearance and antiinflammation. cns neurosci ther. 2017; 23:498–509. y. ding, j. zhang, r. wang*. inhibition of tissue transglutaminase attenuates lipopolysaccharide-induced inflammation in glial cells through akt/ mtor signal pathway. biomedicine & pharmacotherapy 89 (2017) 1310–1319 d. dong, y. mao, c. huang, q. jiao, h. pan, l. ma*, r. wang*: astrocytes mediated the nootropic and neurotrophic effects of sarsasapogenin-aa13 via upregulating brain-derived neurotrophic factor. am j transl res 2017;9(9):4015-4025. d. dong, n. zhou, r. liu, j. xiong, h. pan, s. sun, l. ma*, r. wang* sarsasapogenin-aa13 inhibits lps-induced inflammatory responses in macrophage cells in vitro and relieves dimethylbenzene-induced ear edema in mice. acta pharmacologica sinica (2017) 38: 699–709. h. pan#, p. van khang, d. dong, r. wang*, l. ma*, synthesis and sar study of novel sarsasapogenin derivatives as potent neuroprotective agents and no production inhibitors, bioorganic & medicinal chemistry letters. 27(3), 662-665(2017).(if=2.486) qian r, tong h, huang c, li j, tang y, wang r, lou k, wang w. a donor-acceptor triptycene-coumarin hybrid dye featuring a charge separated excited state and aie properties. org biomol chem. 2016 jun 14;14(22):5007-11. s. li, h. xu, s. cui, f. wu, y. zhang, m. su, y. gong, s. qiu, q. jiao, c. qin, j. shan, m. zhang, j. wang, q. yin, m. xu, x. liu, r. wang, l. zhu, j. li, y. xu, h. jiang, z. zhao, j. li, h. li.. discovery and rational design of natural-product-derived2-phenyl-3,4-dihydro-2h-benzo[f]chromen-3-amine analogs as novel and potentdipeptidyl peptidase 4 (dpp-4) inhibitors for the treatment of type 2 diabetes. journal of medicinal chemistry. 2016, 59: 6772-6790. x. wang#, l. zhou, f. qiang, f. wang, r. wang*, c. zhao*, development of a bodipy-based ratiometric fluorescent probe for hypochlorous acid and its application in living cells, analytica chimica acta 911 (2016) 114-120.(if=4.712) r.x. liu#, c. huang, d.a. bennett, h. li*, r. wang*, the characteristics of astrocyte on abeta clearance altered in alzheimer's disease were reversed by anti-inflammatory agent ( )-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate, american journal of translational research 8 (2016) 4082-4094. (if=3.226) c.c. zhao#*, j.c. an, l. zhou, q. fei, f.y. wang, j. tan, b. shi, r. wang*, z.q. guo, w.h. zhu, transforming the recognition site of 4-hydroxyaniline into 4-methoxyaniline grafted onto a bodipy core switches the selective detection of peroxynitrite to hypochlorous acid, chemical communications 52 (2016) 2075-2078.(if=6.567) x. jia#, q. chen, y. yang, y. tang, r. wang, y. xu, w. zhu, x. qian*, fret-based mito-specific fluorescent probe for ratiometric detection and imaging of endogenous peroxynitrite: dyad of cy3 and cy5, journal of the american chemical society 138 (2016) 10778-10781.(if=13.038) h. tong#, y. zheng, l. zhou, x. li, r. qian, r. wang, j. zhao, k. lou, w. wang*, enzymatic cleavage and subsequent facile intramolecular transcyclization for in situ fluorescence detection of gamma-glutamyltranspetidase activities, analytical chemistry 88 (2016) 10816-10820.(if=5.886) s. li#, h. xu, s. cui, f. wu, y. zhang, m. su, y. gong, s. qiu, q. jiao, c. qin, j. shan, m. zhang, j. wang, q. yin, m. xu, x. liu, r. wang, l. zhu, j. li, y. xu, h. jiang, z. zhao, j. li, h. li*, discovery and rational design of natural-product-derived 2-phenyl-3,4-dihydro-2h-benzo[f]chromen-3-amine analogs as novel and potent dipeptidyl peptidase 4 (dpp-4) inhibitors for the treatment of type 2 diabetes, journal of medicinal chemistry 59 (2016) 6772-6790.（if=2.912）(if=5.589) h. sun#, l. zhou, x.l. chen, x. han, r. wang, h.l. liu*, microscopic insight into the dna condensation process of a zwitterion-functionalized polycation, biopolymers 105 (2016) 802-810.(if=2.248) zhang j, wang s, huang w, bennett da, dickson dw, wang d, wang r*. tissue transglutaminase and its product isopeptide are increased in alzheimer's disease and appswe/ps1de9 double transgenic mice brains. mol neurobiol. 2016 oct;53(8):5066-78. (if=5.137) zhang j, ding yr, wang r*. inhibition of tissue transglutaminase promotes aβ-induced apoptosis in sh-sy5y cells. acta pharmacol sin. 2016;8(10):4082-4094. wang x, zhou l, qiang f, wang f, wang r*, zhao c. development of a bodipy-based ratiometric fluorescent probe for hypochlorous acid and its application in living cells. anal chim acta. 2016 mar 10;911:114-20. zhou l, qian j, liu j, zhao r, li b, wang r*. identification of the sites of 4-hydroxy-2-nonenal and neprilysin adduction using a linear trap quadrapole velos pro-orbitrap elite mass spectrometer. eur j mass spectrom (chichester). 2016;22(3):133-9.(if=1.011) shen jn, xu lx, shan l, zhang wd, li hl, wang r*.neuroprotection of ( )-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate against hydrogen peroxide and lipopolysaccharide induced injury via modulating arachidonic acid network and p38-mapk signaling. curr alzheimer res. 2015;12(9):892-902. .(if=3.953) feiyi wang, li zhou, chunchang zhao,* rui wang, qiang fei, sihang luo, zhiqian guo, he tiana and wei-hong zhu*. a dual-response bodipy-based fluorescent probe for the discrimination of glutathione from cystein and homocystein. chem. sci., 2015, 6, 2584 song c, yang w, zhou n, qian r, zhang y, lou k, wang r, wang w. fluorescent theranostic agents for hg(2 ) detection and detoxification treatment. chem commun (camb). 2015 mar 14;51(21):4443-6. ji zhou, ruiyan shi, jianxu liu, rui wang, yufang xu* and xuhong qian*. an esipt-based fluorescent probe for sensitive detection of hydrazine in aqueous solution. org. biomol. chem., 2015, 13, 5344-5348. junsheng zhu, le han, yanyan diao, xiaoli ren, minghao xu, liuxin xu, shiliang li, qiang li, dong dong, jin huang, xiaofeng liu, zhenjiang zhao, rui wang, lili zhu,* yufang xu, xuhong qian,* and honglin li*. design, synthesis, x ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. j. med. chem. 2015, 58, 1123−1139. feiyi wang, ying zhu, li zhou, liang pan, zhifen cui, qiang fei, sihang luo, dun pan, qing huang†, rui wang, chunchang zhao,* he tian, and chunhai fan*. fluorescent in situ targeting probes for rapid imaging of ovarian- cancer-specific g-glutamyltranspeptidase. angew. chem. int. ed. 2015, 54, 7349 –7353. pham van khang, ting xu, liuxin xu, nannan zhou, lihong hu, rui wang*, lei ma*. steroidal glycosides from marsdenia tenacissima. phytochemistry letters 12 (2015) 54–58. sheng-quan hu, rui wang, wei cui, shing-hung mak, gang li, yuan-jia hu, ming-yuen lee, yuan-ping pang, yi-fan han. dimeric bis(heptyl)-cognitin blocks alzheimer’s β-amyloid neurotoxicity via the inhibition of aβ fibrils formation and disaggregation of pre-formed fibrils. cns neurosci ther. 2015;21(12):953-61. jie zhang*, liu-xin xu*, xu-sheng xu, bo-wei li, rui wang*, jian-jun fu. synthesis and effects of new caffeic acid derivatives on nitric oxide production in lipopolysaccharide-induced raw 264.7 macrophages. int j clin exp med 2014;7(4):1022-1027. chunchang zhao,* jiancai an, li zhou, qiang fei, feiyi wang, jie tan, ben shi, rui wang,* zhiqian guo, wei-hong zhu. transforming the recognition site of 4-hydroxyaniline into 4- methoxyaniline grafted onto a bodipy core switches the selective detection of peroxynitrite to hypochlorous acid. chem commun (camb). 2016 feb 4;52(10):2075-8. doi: 10.1039/c5cc08936k. shen jn, xu lx, wang r*. [cyclooxygenases, lipoxygenases, their targeted drugs and the prevention of alzheimer's disease]. yao xue xue bao. 2013 dec;48(12):1743-54. review. chinese. shen jn, wang ds, wang r*. the protection of acetylcholinesterase inhibitor on -amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells. int j clin exp pathol. 2012;5(9):900-13. shen pc, xu df, liu jw, li k, lin m, wang ht, wang r and zheng j. tc10/cdc42 gtpase activating protein is required for the growth of cortical neuron dendrites neuroscience 199 (2011) 589–597. zheng j, xu df, li k, wang ht, shen pc, lin m, cao xh, wang r. neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal ca1 pyramidal neurons. int j clin exp pathol. 2011;4(2):162-8. wang s, wang r (co-first author), chen l, bennett da, dickson dw, wang ds. expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and alzheimer's brain. j neurochem. 2010;115(1):47-57. wang r, malter js, wang ds. n-acetylcysteine prevents 4-hydroxynonenal- and amyloid-beta-induced modification and inactivation of neprilysin in sh-sy5y cells. j alzheimer’s dis. 2010,19:197-189. wang r, wang s, malter j.s. and wang d. effects of 4-hydroxy-nonenal and amyloid-β on expression and activity of endothelin converting enzyme and insulin degrading enzyme in sh-sy5y cells. j alzheimer’s disease 2009, 17 (3): 489-501 (if=5.101). wang r, wang s, malter js, wang ds. effects of hne-modification induced by abeta on neprilysin expression and activity in sh-sy5y cells. j neurochem. 2008 feb;108(4):1072-82. shaoyun wang, dengshun wang, rui wang. neuroprotective activities of enzymatically hydrolyzed peptides from porcine hide gelatin. int j clin exp med 2008.1(3):283-293. xiao k, li x, li j, ma l, hu b, yu h, fu y, wang r (co-corresponding author), ma z, qiu b, li j, hu d, wang x, shen j. design, synthesis, and evaluation of leu *ala hydroxyethylene-based non-peptide beta-secretase (bace) inhibitors. bioorg med chem. 2006 jul;14(13):4535-51. wang r, yan h, tang xc. progress in studies of huperzine a, a natural cholinesterase inhibitor from chinese herbal medicine. acta pharmacol sin 2006, 27:1-26 (invited review). tang ll, wang r, tang xc. huperzine a protects shsy5y neuroblastoma cells against oxidative stress damage via nerve growth factor production. eur j pharmacol 2005,519:9-15. bao gh, qin gw, wang r, tang xc. morphinane alkaloids with cell protective effects from sinomenium acutum. j nat prod 2005, 68:1128-1130. wang r and tang xc. neuroprotective effects of huperzine a: a natural cholinesterase inhibitor for the treatment of alzheimer’s disease. neurosignals, 2005, 14(1-2): 71-82 (invited review). wang r, boules m, gollatz e, williams k, richelson e. effects of 5 daily injections of the neurotensin-mimetic nt69l on the expression of neurotensin receptors in rat brain. mol brain res, 2005, 138:24-34. tang ll, wang r, tang xc. effects of huperzine a on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat pc12 cells. acta pharmacol sin. 2005, 26:673-678. wang r, boules m, tiner w, richelson e. effects of 5 daily injections of the neurotensin-mimetic nt69l on dopamine release and uptake in rat striatum in vitro. brain res. 2004,1025:21-28. liao y, wang r, tang x.c. centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal drgeneration in rats. acta pharmacol. sin. 2004, 25(12): 1590-1596. boules m, mcmahon b, wang r, warrington l, stewart j, yerbury s, fauq a, mccormick d and richelson e. selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood brain barrier. brain res. 2003. 987(1):39-48. wang r, zhou j, tang, xc. tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat pc12 cells. brain res. mol. brain. res. 2002, 107(1):1-8. wang r, xiao xq and tang xc. huperzine a attenuates hydrogen peroxide-induced apoptosis and pro-apoptosis gene expression in rat pc12 cells. neuroreport. 2001, 12 (12), 2629-2634. wang r, zhang hy and tang xc. huperzine a attenuates cognitive dysfunction and neuronal degeneration caused by b-amyloid protein 1-40 in rat. eur j pharmacol. 2001, 421,149-156. xiao xq, wang r, han yf and tang xc. protective effects of huperzine a on b-amyloid25-25 induced oxidative injury in rat pheochromocytoma cells. neursci lett, 2000; 286(3): 155-158. xiao xq, wang r, and tang xc. huperzine a and tacrine attenuate b-amyloid peptide induced oxidative injury. j neurosci res, 2000.61:564-569. wang r, yang qf, tang yp, et al. improvement for rat’s imitative “vascular dementia model”. chinese journal of pathophysiology, 2000. 16(10): 914-916 (chinese). wang r, yang qf, tang yp, et al. studies on rat imitative vascular dementia model and protective effects of traditional chinese herbs 9602. acta of beijing university of traditional medicine. 2000. 23(5): 30-32 (chinese). wang r, yang qf, tang yp, et al. studies on the dynamic changes in power of rat’s ecog and ehg after cerebral ischemia /refusion and preventive effects of traditional medicine 9602. chinese journal of pathophysiology. in press (chinese). wang r, fang lm, yang qf. experimental studies of chinese medicine 9602 attenuating toxicity of glutamic acid. chinese journal of integrated traditional and western medicine. 2001, in press (chinese). wang r, fang lm, yang qf, et al. studies on relationship between alterations of hippocampal evoking population spike in ca1 region and neuronal apoptosis after transient ischemia along with improving effects of chinese herbs 9602. chinese journal of pathophysiology. in press(chinese). chen xm, xu rl, wang r, et al. studies on galactosamine-induced rat’s model of fulminant hepatic failure. the journal of shanxi medicine 1991: 20(5): 293-295 (chinese). wang r, chen xm, xu rl, et al. studies on the pathogenesis of renal insufficiency in acute hepatic failure. chinese journal of pathophysiology 1991; 7(5): 482-485 (chinese). chen xm, wang r, xu rl, et al. a gravimetric technique for measurement of cerebral edema. chinese journal of pathophysiology 1992; 8(3): 301-303 (chinese). yin l, zhao yc, xu rl, chen xm and wang r. the therapeutic effect of poria for experimental cirrhosis. acta of shanxi medical university 1992; 3(2): 101-103 (chinese). wang r, yin l, li cm, et al. roles for prostaglandin i2 and thromboxane a2 in experimental hepatorenal syndrome. chinese journal of hepatology 1994; 2(4): 210-212 (chinese). wang r, yin l, li cm, et al. the preventive and theraputic effects of radix salviae miltiorrhizae for the experimental hepatorenal syndrome. journal of shanxi clinical medicine. 1995; supplement; 172-174 (chinese). wang r, yin l, li cm, et al. an animal model of hepatorenal syndrome. acta of shanxi medical university 1995;(4):277-279 (chinese). liu jc, li rx, yan z, han dw, wang r, ma xh. the effect of endothelin on renal function in cirrhosis. chinese journal of pathophysiology 1998; 14(6): 717-719 (chinese). wang r, yin l, li cm, liu jc. the dynamic changes of renal ltc4 in acute hepatic failure. chinese journal of pathophysiology 1998; 14(6): 720-722 (chinese). wang r, li cm, han dw, liu jc. effects of endothelin on renal insufficiency in acute hepatic failure. chinese journal of pathophysiology 1999; 15(2): 154-156 (chinese).
research support national science foundation of china (no.81072627), pi. foundation from ministry of science and technology of china (g199805110, g199805115), key personnel. foundation from ministry of science and technology of china (2004cb518907), co-pi. national science foundation of china (no.30123005, 3001161954), participant or key personnel. national science foundation of china (no.30572169), pi. committee of shanghai science and technology (1243900900), pi. foundation for drug discovery from committee of shanghai science and technology (44319214), co-pi.
patents lei ma, rui wang, nannan zhou, ting xu, jianhong zhao, ji zhang, guozhong zhang, liuxin xu, yaqin y，jiawei xiong, huanhuan yin, hui pan. modification, pharmaceutical composition and application of sarsasapogenin derivatives. chinese patent. authorization number: zl201510042229.6 2. gw qin, xc tang, r wang, tx zhou, p. lestage, d-h caignard, p renard. sinomenine and sinomenine compounds, synthesis and use. pct patent. application number: pct/ep2003/014841. publiction number: wo2004/048340 3. gw qin, xc tang, r wang, tx zhou, p. lestage, d-h caignard, p renard. sinomenine and sinomenine compounds, synthesis and use. chinese patent. application number: 02153819.0. publiction number: cn 1504469a 4. dl bai, s feng, xc he, xc tang, r wang. bis-huperzine b, bis-huperzine b derivatives, synthesis and use. chinese patent. application number: 200310108598.8 5.jk shen, k xiao, j li, r wang, jy li, x li, lp ma, zq ma, b hu, hp yu,y fu,by qiu, x wang, dy hu. the preparation and application of a series of hydroxyethylene based compounds. pct patent. application number: pct/cn2006/000035. 6. yufang xu, xin wang, lei cui, rui wang, xuhong qian, weiping zhu, nannan zhou. the fluorescent probes for detection of n- acetyl transferase 2. chinese patent. application number: 201310149127.5
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