|
|
杨武林 副教授 博士生导师
e-mail：yangwl@ecust.edu.cn
邮 编：200237
通讯地址：上海市徐汇区梅陇路130号华东理工大学实验18楼1121室
【教育背景】
1. 2012.09–2017.09，华东理工大学，药学专业，博士，导师：邓卫平 教授
2. 2016.09–2017.08，美国罗格斯大学，国家公派联合培养博士生，导师：daniel seidel 教授
3. 2008.09–2012.07，华东理工大学，药物制剂专业，学士
【工作经历】
1. 2023.07–至今，华东理工大学，药学院，副教授，博士生导师
2. 2021.09–2023.06，华东理工大学，药学院，副教授，硕士生导师
3. 2019.12–2021.08，华东理工大学，药学院，特聘副研究员，硕士生导师
4. 2017.10–2019.12，华东理工大学，药学院，师资博士后，合作导师：李忠 教授
【研究方向】
1. 新型杂环骨架导向的手性技术开发
2. 新型合成方法驱动的农药创新研究
3. 药物、农药绿色合成工艺创新研究
【招生专业】
1. 博士
植物保护 (代码: 090400)
2. 学术型硕士
制药工程与技术 (代码: 0817z3)
植物保护 (代码: 090400)
3. 专业型硕士
生物与医药 (代码: 086000)
【科研业绩】
近年来，主要围绕新型手性杂环骨架的高效精准构筑及相关生物活性研究等方面开展了系统性研究工作。以第一作者或通讯作者在angew. chem. int. ed. (4篇)、acs catal. (3篇)等期刊上发表sci论文30余篇。作为项目负责人主持国家自然科学基金面上项目(2021)、国家自然科学基金青年基金项目(2019)、上海市自然科学基金面上项目(2023)、上海市农业科技创新春蕾项目(2023)、中国博士后科学基金特别资助(2019)、中国博士后科学基金面上资助(2018)等科研项目。曾荣获或入选上海市优秀毕业生(2017)、上海市博士后日常工作经费资助(2017)、上海市青年科技英才扬帆计划(2018)、上海产学研合作优秀项目奖三等奖(2021)、上海市青年科技启明星计划a类(2023)、华东理工大学青年英才培育计划a类(2022)、华东理工大学药学院科研之星(2023)。
【代表性论文】（#共同第一作者, *通讯作者）
chen diancong#, zhang man#, zhang dongxu#, zhang ziqi, shao xusheng, xu xiaoyong, li zhong, yang wu-lin*. iridium/acid dual-catalyzed enantioselective aza-ene-type allylic alkylation of nitro ketene aminals with racemic allylic alcohols. org. lett., 2024, 26(2), 508-513.
liang junqing#, fu wen#, dong lefeng, zhou cong, yuan qinglong, chang wenning, yang wu-lin*, xu xiaoyong, shao xusheng, li zhong*. n‑difluoromethylthiophthalimide reagents for modular synthesis of diversified α‑difluoromethylthiolated ketones. org. lett., 2023, 25(26), 4797-4802.
yan hui, shao xusheng, xu xiaoyong, li zhong*, yang wu-lin*. ir-catalyzed asymmetric cascade allylation/spiroketalization reaction for stereoselective synthesis of oxazoline-spiroketals. org. lett., 2023, 25(2), 325-330.
yan hui, zhang man, li lin, hu teng, yang wu-lin*. advances in the catalytic asymmetric synthesis of chiral spiroketals. chin. j. org. chem., 2022, 42(11), 3640-3657.
yang wu-lin*, shang xin-yu, ni tao, yan hui, luo xiaoyan, zheng hanliang*, li zhong, deng wei-ping*. diastereo- and enantioselective synthesis of bisbenzannulated spiroketals and spiroaminals by ir/ag/acid ternary catalysis. angew. chem. int. ed., 2022, 61(42), e202210207.
yang wu-lin*, shen jia-huan, zhao zeng-hui, wang zhongao, deng wei-ping*. stereoselective synthesis of functionalized azepines via gold and palladium relay catalysis. org. chem. front., 2022, 9(17), 4685-4691.
yang wu-lin#*, shang xin-yu#, luo xiaoyan, deng wei-ping*. enantioselective synthesis of spiroketals and spiroaminals via gold and iridium sequential catalysis. angew. chem. int. ed., 2022, 61(26), e202203661.
zhang jian, yang wu-lin*, zheng hanliang, wang yi, deng wei-ping*. regio- and enantioselective γ-allylic alkylation of in situ-generated free dienolates via scandium/ iridium dual catalysis. angew. chem. int. ed., 2022, 61(19), e202117079.
shen jia-huan#, tian fei#, yang wu-lin*, deng wei-ping*. synergistic copper and chiral lewis base catalysis for the asymmetric synthesis of pyrrolo[1,2-a]indoles. chin. j. chem., 2021, 39(12), 3292-3296.
yang wu-lin*, wang yuan-lin, li wen, gu bu-ming, wang si-wen, luo xiaoyan, tian bo-xue*, deng wei-ping*. diastereo- and enantioselective synthesis of eight-membered heterocycles via an allylation/ring expansion sequence enabled by multiple catalysis. acs catal., 2021, 11(20), 12557-12564.
yang wu-lin#*, liu tian-tian#, ni tao, zhu bin, luo xiaoyan, deng wei-ping*. iridium-catalyzed asymmetric cascade allylation/pictet-spengler cyclization reaction for the enantioselective synthesis of 1,3,4-trisubstituted tetrahydroisoquinolines. org. lett., 2021, 23(7), 2790-2796.
zhang jian, gao yan-shan, gu bu-ming, yang wu-lin*, tian bo-xue*, deng wei-ping*. cooperative n‑heterocyclic carbene and iridium catalysis enables stereoselective and regiodivergent [3 2] and [3 3] annulation reactions. acs catal., 2021, 11(7), 3810-3821.
yang wu-lin#, ni tao#, deng wei‐ping*. iridium-catalyzed diastereo- and enantioselective [4 3] cycloaddition of 4‑indolyl allylic alcohols with azomethine ylides. org. lett., 2021, 23(2), 588-594.
tian fei#, yang wu‐lin#*, ni tao, zhang jian, deng wei‐ping*. catalytic asymmetric dipolar cycloadditions of indolyl delocalized metal-allyl species for the enantioselective synthesis of cyclopenta[b]indoles and pyrrolo[1,2-a]indoles. sci. china chem., 2021, 64(1), 34-40.
ye chao#, yang wu‐lin#, zhai yufei, deng hua, luo xiaoyan*, kai guoyin*, deng wei-ping. copper(i)-catalyzed asymmetric [3 3] annulation involving aziridines to construct tetrahydro-β-carbolines. org. chem. front., 2020, 7(21), 3393-3398.
yang wu‐lin#, huang zesheng#, liu yang‐zi, yu xingxin*, deng wei‐ping*. highly regio‐, diastereo‐, and enantioselective assembly of azepino[2,3‐b]indoles via palladium‐catalyzed [4 3] cycloaddition. chin. j. chem., 2020, 38(12), 1571-1574.
tian fei#, zhang jian#, yang wu-lin*, deng wei-ping*. progress in iridium-catalyzed asymmetric allylic substitution reactions via synergetic catalysis. chin. j. org. chem., 2020, 40(10), 3262-3278.
zhang jian, ni tao, yang wu-lin*, deng wei-ping*. catalytic asymmetric [3 2] annulation via indolyl copper-allenylidene intermediates: diastereo- and enantioselective assembly of pyrrolo[1,2-a]indoles. org. lett., 2020, 22(11), 4547-4552.
yang wu-lin*, li wen, yang zhong-tao, deng wei-ping*. organocatalytic regiodivergent ring expansion of cyclobutanones for the enantioselective synthesis of azepino[1,2‑a]indoles and cyclohepta[b]indoles. org. lett., 2020, 22(10), 4026-4032.
zou xue-jie, yang wu-lin*, zhu jing-yan, deng wei-ping*. catalytic enantioselective formal synthesis of mdm2 antagonist rg7388 and its analogue. chin. j. chem., 2020, 38(5), 435-438.
zheng xing, sun hao, yang wu-lin*, deng wei-ping*. elaboration of phosphoramidite ligands enabling palladium-catalyzed diastereo- and enantioselective all carbon [4 3] cycloaddition. sci. china chem., 2020, 63(7), 911-916.
zou xuejie, liu yangzi, shang shaojing, yang wulin*, deng weiping*. diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a [3 3] cycloaddition of 2,2'-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones. chin. chem. lett., 2020, 31(5), 1293-1296.
yang wulin, wang hao, pan zirong, li zhong*, deng weiping. asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic [3 2] annulation of substituted 2-vinylindoles with azlactones. chin. chem. lett., 2020, 31(3), 721-724.
liu yang-zi, wang zhongao, huang zesheng, zheng xing, yang wu-lin*, deng wei-ping*. palladium-catalyzed asymmetric [4 3] cyclization of trimethylenemethane: regio-, diastereo-, and enantioselective construction of benzofuro[3,2-b]azepine skeletons. angew. chem. int. ed., 2020, 59(3), 1238-1242.
chen long#, yang wu-lin#*, shen jia-huan, deng wei-ping*. nickel(ii)-catalyzed diastereo- and enantioselective michael/hemiacetalization cascade reaction of α-ketoesters with 2-(2-nitrovinyl)phenols. adv. synth. catal., 2019, 361(19), 4611-4622.
yang wu-lin, sun zhong-tao, sun hao, deng wei-ping*. nickel(ii)-catalyzed diastereo- and enantioselective [3 2] cycloaddition of α-ketoesters with 2-nitrovinylindoles and 2-nitrovinylpyrroles. chin. j. chem., 2019, 37(3), 216-220.
yang wu-lin, sun zhong-tao, zhang jian, li zhong*, deng wei-ping. enantioselective synthesis of 3-amino-hydrobenzofuran-2,5-diones via cu(i)-catalyzed intramolecular conjugate addition of imino esters. org. chem. front., 2019, 6(5), 579-583.
gu bo-qi, yang wu-lin*, wu shu-xiao, wang yan-bing, deng wei-ping*. organocatalytic asymmetric synthesis of tetrahydrocarbazoles via an inverse-electron demand diels-alder reaction of 2,3-indole-dienes with enals. org. chem. front., 2018, 5(23), 3430-3434.
ding xiang-feng, su ruo-heng, yang wu-lin*, deng wei-ping*. organocatalytic asymmetric formal aza-[3 3] cycloadditions of 3-aminobenzofuran with α,β-unsaturated aldehydes. adv. synth. catal., 2018, 360(21), 4168-4177.
deng hua, yang wu-lin*, tian fei, tang wenjun, deng wei-ping*. asymmetric construction of 3-azabicyclo[3.1.0]hexane skeleton with five contiguous stereogenic centers by cu-catalyzed 1,3-dipolar cycloaddition of trisubstituted cyclopropenes. org. lett., 2018, 20(13), 4121-4125.
tian fei, he fu-sheng, deng hua, yang wu-lin*, deng wei-ping*. β-silyl acrylates in asymmetric [3 2] cycloadditions affording pyrrolidine azasugar derivatives. org. lett., 2018, 20(13), 3838-3842.
zheng xing, yang wu-lin*, liu yang-zi, wu shu-xiao, deng wei-ping*. enantioselective synthesis of tropanes via [3 3] annulation of cyclic azomethine ylides with substituted 2-vinylindoles and 2-vinylpyrroles. adv. synth. catal., 2018, 360(15), 2843-2853.
liu yang-zi, shang shao-jing, zhu jing-yan, yang wu-lin*, deng wei-ping*. regioselective and stereoselective [3 3] annulation of ketones derived azomethine ylides with 2-indolylethylenes: direct access to highly substituted tetrahydro-γ-carbolines. adv. synth. catal., 2018, 360(11), 2191-2203.
zhu jing-yan, yang wu-lin*, liu yang-zi, shang shao-jing, deng wei-ping*. copper(i)-catalyzed asymmetric mannich reaction of glycine schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles. org. chem. front., 2018, 5(1), 70-74.
yang zhong-tao, yang wu-lin*, chen long, sun hao, deng wei-ping*. organocatalytic enantioselectiveaza-friedel-crafts reactions of pyrazolinone ketimines with hydroxyindoles and electron-rich phenols. adv. synth. catal., 2018, 360(10), 2049-2054.
yang wu-lin, li chun-yan, qin wen-jing, tang fei-fei, yu xingxin, deng wei-ping*. cu(i)-catalyzed chemoselective and stereoselective [3 3] cycloaddition of azomethine ylides with 2-indolylnitroethylenes: facile access to highly substituted tetrahydro-γ-carbolines. acs catal., 2016, 6(9), 5685-5690.
yang wu-lin, tang fei-fei, he fu-sheng, li chun-yan, yu xingxin*, deng wei-ping*. asymmetric construction of spirocyclic pyrrolidine-thia(oxa)zolidinediones via n,o-ligand/cu(i)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 5-alkylidene thia(oxa)zolidine-2,4-diones. org. lett., 2015, 17(19), 4822-4825.
yang wu-lin, liu yang-zi, luo shuai, yu xingxin*, fossey john s., deng wei-ping*. copper- catalyzed asymmetric construction of dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides with α-alkylidene. chem. commun., 2015, 51(44), 9212-9215.
li chun-yan#, yang wu-lin#, luo xiaoyan*, deng wei-ping*. diastereodivergent asymmetric michael addition of cyclic azomethine ylides to nitroalkenes: direct approach for the synthesis of 1,7-diazaspiro[4.4]nonane diastereoisomers. chem. eur. j., 2015, 21(52), 19048-19057.
|
地址：上海市徐汇区梅陇路130号 邮编：200237
2024欧洲杯官方网站的版权所有 © 2023 华东理工大学药学院 |
